House Call: Colorectal Cancer Awareness ? Importance of ...

According to a study published in the New England Journal of Medicine, colon exams cut death risk from colorectal cancer in half.

People ages 50 to 75 are most likely to get colon cancer, but only about half of the people that fall into that age bracket in the U.S. get screened.? Colonoscopies are the gold standard of screening methods for colorectal cancer.

Colorectal cancer occurs in men and women equally, therefore it is recommended for everyone to begin getting colonoscopies at the age of fifty, unless there is a family history of the disease.

More: Colorectal Cancer Statistics Sheet

Signs and symptoms of colorectal cancer include rectal bleeding, substantial change in bowel habits, unexplained abdominal pain and/or unusual weight loss. Symptoms of colorectal cancer most often present in the late stages of the disease, when treatment and curing it can prove much more difficult. Risk for developing colorectal cancer increases with age and family history of the disease, but most cases of colorectal cancer are spontaneous.

The late presenting symptoms and spontaneity of the disease also emphasize the importance of getting screened through the use of colonoscopy. Through the use of colonoscopy, gastroenterologists can not only detect and diagnose malignancies in the colon, but they can also detect and remove possibly pre-cancerous polyps lining the colon?significantly decreasing risk of developing colorectal cancer.

Despite common belief, colonoscopies are painless procedures in which the patient is properly sedated and gastroenterologists are actually able to remove any polyps discovered during the colonoscopy procedure as well.

Cone Health is dedicated to building colorectal awareness in the community, and is holding a colorectal cancer seminar and screening on Monday, March 4th at the Cone Health Cancer Center. The seminar is free, but registration is required. To register, call 832-8000 or visit conehealth.com.

Spokesperson Background:

Dan Madden is a registered nurse at Cone Health Endoscopy Department. He received an Associate Degree in Nursing from Guilford Technical Community College in 1998. Dan also became a certified gastroenterology registered nurse in 2012. He has been a Cone Health employee since 1985.

Source: http://myfox8.com/2013/02/25/house-call-colorectal-cancer-awareness-importance-of-screening/

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Sterling struggles after UK debt downgrade

LONDON (AP) ? The British pound is recovering after dropping against the world's leading currencies as markets reacted to a downgrade of the U.K.'s cherished triple-A credit rating.

During early trading Monday, sterling dropped to $1.5069 against the dollar ? its lowest level since July 2010 ? before bouncing back to $1.5144. Against the euro, the pound hovered around 18-month lows with one euro worth 0.8745 pound.

The pound was in focus in the wake of last Friday's decision by Moody's to downgrade the U.K.'s credit rating by one notch from the top AAA to AA1. The agency says sluggish growth and rising debt are weakening the British economy's outlook.

Two other major rating agencies ? Fitch and Standard & Poor's ? have also warned that they may downgrade the U.K. as well.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2013-02-25-Britain-Economy/id-e473c57ff48746bfbf1ce0929da2edd5

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Target: Cancer

Public release date: 26-Feb-2013
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Contact: Denise Henry
henryd@uakron.edu
330-972-6477
University of Akron

New microscopy technique shows how receptor malfunctions in cancer cell membranes

For scientists to improve cancer treatments with targeted therapeutic drugs, they need to be able to see proteins prevalent in the cancer cells. This has been impossible, until now. Thanks to a new microscopy technique, University of Akron researcher Dr. Adam Smith, assistant professor of chemistry, has observed how clusters of epidermal growth factor receptor (EGFR) a protein abundant in lung and colon cancers, glioblastoma and others malfunctions in cancer cells.

"We can directly observe protein clusters, in a living cell membrane, that are invisible to traditional methods. This opens up the possibility to directly measure the effect of drugs on the target proteins," Smith says.

Smith's work lies at the heart of current-day cancer research, which focuses on developing targeted drugs that kill cancer cells without the collateral damage associated with traditional treatments like chemotherapy.

Specifically, Smith used a cutting-edge photon-counting technique, which enables scientists to measure the cluster size of EGFR proteins. The technique represents a significant advancement from studying the cultures with a traditional microscope, which cannot visually capture objects as small as the EGFR clusters, according to Smith, a lead author of "Conformational Coupling across the Plasma Membrane in Activation of the EGF Receptor," published in the Jan. 31 journal Cell, which highlights the technique.

"Another difficulty with studying EGFR is that it's located in the cell membrane, which can be thought of as a fence line that defines the cell boundary, but in reality it is more like an untamed hedge row," says Smith, explaining how the new laser-based microscope technique overcomes that obstacle and allows scientists to study, in real time, how EGFR works in healthy cells and also how it malfunctions in cancer cells.

Smith's subsequent work studying the interaction of drugs with the targeted EGFR "will significantly improve drug discovery, which too often relies on indirect measure of efficacy," he says.

###

Partners in Smith's research include scientists from the University of California, Berkeley, and Columbia University. The National Center Institute, Howard Hughes Medical Institute and the U.S. Department of Energy provided funding for this research.

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?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 26-Feb-2013
[ | E-mail | Share ]

Contact: Denise Henry
henryd@uakron.edu
330-972-6477
University of Akron

New microscopy technique shows how receptor malfunctions in cancer cell membranes

For scientists to improve cancer treatments with targeted therapeutic drugs, they need to be able to see proteins prevalent in the cancer cells. This has been impossible, until now. Thanks to a new microscopy technique, University of Akron researcher Dr. Adam Smith, assistant professor of chemistry, has observed how clusters of epidermal growth factor receptor (EGFR) a protein abundant in lung and colon cancers, glioblastoma and others malfunctions in cancer cells.

"We can directly observe protein clusters, in a living cell membrane, that are invisible to traditional methods. This opens up the possibility to directly measure the effect of drugs on the target proteins," Smith says.

Smith's work lies at the heart of current-day cancer research, which focuses on developing targeted drugs that kill cancer cells without the collateral damage associated with traditional treatments like chemotherapy.

Specifically, Smith used a cutting-edge photon-counting technique, which enables scientists to measure the cluster size of EGFR proteins. The technique represents a significant advancement from studying the cultures with a traditional microscope, which cannot visually capture objects as small as the EGFR clusters, according to Smith, a lead author of "Conformational Coupling across the Plasma Membrane in Activation of the EGF Receptor," published in the Jan. 31 journal Cell, which highlights the technique.

"Another difficulty with studying EGFR is that it's located in the cell membrane, which can be thought of as a fence line that defines the cell boundary, but in reality it is more like an untamed hedge row," says Smith, explaining how the new laser-based microscope technique overcomes that obstacle and allows scientists to study, in real time, how EGFR works in healthy cells and also how it malfunctions in cancer cells.

Smith's subsequent work studying the interaction of drugs with the targeted EGFR "will significantly improve drug discovery, which too often relies on indirect measure of efficacy," he says.

###

Partners in Smith's research include scientists from the University of California, Berkeley, and Columbia University. The National Center Institute, Howard Hughes Medical Institute and the U.S. Department of Energy provided funding for this research.

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2013-02/uoa-tc022613.php

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Take the Guesswork Out of the Recruiting Process | ThinkSales

Sales roles vary widely and place very different demands on the people fulfilling them. Profiling your entire sales team prevents you from making all the obvious blunders in sales management, like confusing farmers, who work existing accounts, with hunters, who bring in new business.

However, before you even think about profiling your sales team, you have to have completed these five exercises:

1. Conduct a thorough market analysis
Look at the sectors you are targeting, including their size and growth rates as well as other characteristics. This will enable you to size the sales team correctly.

2. Identify target market and revenue potential
Compile a list of the major customer groups in your target market, and do a potential spend analysis on each one, so that you know how much time, effort and resources you are going to invest.

3. Describe the structure of your sales team
Typically, a sales team comprises a sales manager, assistant sales manager, team leaders and sales executives. You may also have strategic account managers, line of business managers, telesales people and more.

4. Match your team to the market
Define the size of your sales team in line with the needs of your target market and how you are going to achieve sales targets.

5. Develop the sales strategy
Successful strategies help the sales force focus on target market customers and communicate with them in relevant, meaningful ways to ensure customer acquisition and retention.

Once you have completed these steps, you are ready to allocate roles to your sales team. As you create a profile for each job within the entire sales function, bear in mind that this is your blueprint for defining the person who has to do the job. A job profile is not a job description.

Jobs can only be profiled once your sales strategy is in place, as this will enable you to structure each one of the jobs that creates your overall sales team. Once you have identified what your team should look like, the deliverable for each job can be aligned to your strategy to ensure it delivers against it.

The key deliverables will define the talent you need and the specifications for each individual function that makes up the sales team. For example, in today?s economy, the most successful sales people are true consultants who have invested a lot of time in understanding the products and services they sell and the benefits to their customers. The role of sales consultant is not one required in a transactional type of business, but certainly in a consultative business where the organisation focuses on partnering with its clients.

Selling to C-level executives

The role of sales consultant is currently one of the most difficult positions to recruit for, largely because the world has changed since the recession. Middle managers are no longer signing orders ? instead, sales consultants have to engage with people in the C-suite, which has all sorts of implications for the talent specification. It?s absolutely essential to get the right talent on board upfront because of this critical sales exposure. One of biggest drawbacks of not profiling correctly in this instance, is the subsequent loss of opportunity.

Reaping the benefits

Profiling is something that anyone in sales management should be doing, because when it comes to sales people, job interviews are simply not enough. You may, for instance, come across a candidate with experience and an excellent track record, but how will you know if that is purely the result of having had an exceptional product to sell.

In a different environment, perhaps, that person may be quite average. What you should be looking out for is the ability to be competitive and self-motivated ? elements of personality which cannot be taught. Profiling enables you to identify behaviours and requirements of the job to help you recruit the right people for the right job, identify development needs, redraft roles and deploy talent as required.

It indicates the talent required for the job in a scientific manner based on what the job entails, which itself is linked back to the business strategy and the sales targets. Simply, it helps you understand specific behaviours that lead to the most effective performance in a particular job.

Select candidates who add value

Profiling often assesses people according to two different criteria:

• The talent available in the individual candidate which matches the talent requirements
• The knowing or mastery that person has of the sales process.

Once you have insight into the how and the mastery, you will be able to determine if that individual is going to add value when it comes to execution and achieving the business strategy.

Source: http://www.thinksales.co.za/take-the-guesswork-out-of-the-recruiting-process

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Chinese state councilor lauds China-S. Korea ties

Shanghai News.Net - Sunday 24th February, 2013

China's economic growth is expected to pick up 0.43 percentage points from last year to reach 8.23 percent in 2013, China Daily reported Sunday. Export growth will accelerate to 12.22 percent this ...

China Reports Years Second Bird Flu Death

Shanghai News.Net - Saturday 23rd February, 2013

Chinese health officials say a man in southwestern China has died of bird flu, the second fatality from the H5N1 virus this year. The Guizhou provincial health department said Saturday that ...

Chinese state councilor lauds China-S. Korea ties

Global Times - Sunday 24th February, 2013

Chinese State Councilor Liu Yandong applauded the development of China-South Korea ties during a meeting Sunday with outgoing President Lee Myung-bak.Liu, a special envoy of President Hu Jintao and ...

Iran says 16 more nuke power plants coming

Middle East Times - Saturday 23rd February, 2013

Iran's atomic energy agency said Saturday it plans to built 16 nuclear power plants throughout the country. The Atomic Energy Organization of Iran said the facilities are in accord with ...

Chinas countrymen struggling with a sick Mother Earth

The Telegraph - Saturday 23rd February, 2013

In the villages around Baiyin City experts believe the problem is not cancer, but heavy metal poisoning. No official explanation exists for the mysterious leg pains but studies have detected ...

Modern Shanghai Opens at the SM Mall of Asia

General Sources - Saturday 23rd February, 2013

Through the Bistro Group of Restaurants, food lovers in the country can experience the savory world of Shanghainese cuisine with the recent opening of Modern Shanghai, the newest dining concept in ...

Source: http://www.shanghainews.net/index.php/sid/212789797/scat/360231fd461d67ac

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Memory strategy may help depressed people remember the good times

Feb. 25, 2013 ? New research highlights a memory strategy that may help people who suffer from depression in recalling positive day-to-day experiences.

The study is published in Clinical Psychological Science, a journal of the Association for Psychological Science.

Previous research has shown that being able to call up concrete, detailed memories that are positive or self-affirming can help to boost positive mood for people with a history of depression. But it's this kind of vivid memory for everyday events that seems to be dampened for people who suffer from depression.

Researcher Tim Dalgleish of the Medical Research Council Cognition and Brain Sciences Unit and colleagues hypothesized that a well-known method used to enhance memory -- known as the "method-of-loci" strategy -- might help depressed patients to recall positive memories with greater ease.

The method-of-loci strategy consists of associating vivid memories with physical objects or locations -- buildings you see on your commute to work every day, for instance. To recall the memories, all you have to do is imagine going through your commute.

In the study, depressed patients were asked to come up with 15 positive memories. One group was asked to use the method-of-loci strategy to create associations with their memories, while a control group was asked to use a simple "rehearsal" strategy, grouping memories based on their similarities.

After practicing their techniques, the participants were asked to recall as many of their 15 positive memories as they could.

The two methods were equally effective on the initial memory test conducted in the lab -- both groups were able to recall nearly all of the 15 memories.

But the strategies were not equally effective over time.

After a week's worth of practice at home, the participants received a surprise phone call from the researchers, who asked them to recall the memories one more time.

Participants who used the method-of-loci technique were significantly better at recalling their positive memories when compared to those who used the rehearsal technique.

These data suggest that using the method-of-loci technique to associate vivid, positive memories with physical objects or locations may make it easier for depressed individuals to recall those positive memories, which may help to elevate their mood in the long-term.

In addition to Dalgleish, co-authors on this research include Lauren Navrady, Elinor Bird, Emma Hill, Barnaby Dunn and Ann-Marie Golden, all of the Medical Research Council Cognition and Brain Sciences Unit.

This research was supported by the U.K. Medical Research Council.

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Story Source:

The above story is reprinted from materials provided by Association for Psychological Science.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. T. Dalgleish, L. Navrady, E. Bird, E. Hill, B. D. Dunn, A.-M. Golden. Method-of-Loci as a Mnemonic Device to Facilitate Access to Self-Affirming Personal Memories for Individuals With Depression. Clinical Psychological Science, 2013; DOI: 10.1177/2167702612468111

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/living_well/~3/l9PNtGchdOo/130225122047.htm

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NYC woman: Husband, a cop, wanted to kill, eat me

NEW YORK (AP) ? The estranged wife of a New York City police officer struggled to keep her composure Monday as she testified about discovering shocking emails and other evidence on his computer showing he had discussed abducting, torturing and eating her and other women.

"I was going to be tied up by my feet and my throat slit and they were going to watch the blood drain out of me," Kathleen Mangan-Valle told a Manhattan jury.

Mangan-Valle, 27, also read about plans to put one friend in a suitcase, wheel her out of her building and murder her. Two other women were "going to be raped in front of each other to heighten their fears," while another was going to be roasted alive over an open fire, she said.

"The suffering was for his enjoyment and he wanted to make it last as long as possible," she said.

Mangan-Valle broke down in tears several times, but the emotional peak of the day came when a defense attorney showed her pictures of Officer Gilberto Valle in uniform feeding their newborn daughter, prompting both she and Valle to openly weep as the judge sent the jury away for an afternoon break.

The drama came on the first day of testimony at the closely watched trial of the 28-year-old Valle, a baby-faced defendant dubbed the "Cannibal Cop" by city tabloids.

Valle is accused of conspiring to kidnap a woman and unauthorized use of a law enforcement database that prosecutors say he used to help build a list of potential targets. A conviction on the kidnapping count carries a possible life sentence.

The officer has claimed his online discussions of cannibalism were harmless fetish fantasies. But in opening statements on Monday, a prosecutor said "very real women" were put in jeopardy.

"Make no mistake," said Assistant U.S. Attorney Randall Jackson. "Gilbert Valle was very serious about these plans."

Defense attorney Julia Gatto argued that her client "never intended to kidnap anyone." She added: "You can't convict people for their thoughts, even if they're sick."

A college graduate and New York Police Department patrolman, Valle appeared to be leading a normal life before "things got bad," his wife said. "Weird stuff started happening."

Mangan-Valle testified her husband began asking questions about where she liked to jog, what the lighting was like and whether other people were around. Using spyware on his computer, she said she uncovered gruesome photos and the names, heights, weights of women.

She also found that he had visited a fetish website that featured images of dead women.

"I was scared. ... I'd never seen that before," she said.

Once Mangan-Valle fled her home and reported his strange behavior to the FBI last year, agents uncovered "a heinous plot to kidnap, rape, murder and cannibalize a number of very real women," Jackson said.

The officer had attempted to contact potential victims, including a New York City elementary school teacher, to learn more about their jobs and residences, the prosecutor said. His Internet research also included the best rope to tie someone up with, recipes, human flesh, white slavery and chemicals that can knock someone out, Jackson said.

Gatto countered in her opening statement that there was "no proof of a crime here. The charges are pure fiction."

Valle, she said, had always been aroused by "unusual things" including the thought of a woman boiled down on a platter with an apple in her mouth, his lawyer said. He found a home at a fetish website with 38,000 registered members, where regulars discuss "suffocating women, cooking and eating them," she said.

The defense has denied that Mangan-Valle was a potential victim. Valle had made clear that his wife "was unavailable for any kidnapping fantasy," the defense has said in court papers.

On cross-examination, Gatto asked Mangan-Valle if she declined to meet with the defense before the trial began.

"You're representing the man who wants to kill me," she responded. "No I don't want to talk to you."

Valle is expected to take the stand to make the case that it was all role-playing fantasy. The defense also is planning to call experts to explain the fetish subculture and to show jurors the videotaped testimony of the fetish website's co-founder Sergey Merenkov.

Merenkov called the site "a clone of Facebook, but it is oriented to people with fetishes that are not considered standard." Asked about the most popular fetishes, he responded, "All sorts of asphyxiation" and "peril cannibalism."

Tiger Howard Devore, a psychologist and certified sex therapist who specializes in dealing with sexual dysfunction and fetishes, said the cannibalism fetish known as voreaphilia isn't common.

"For most laymen, they're going to think about it as cannibalism," Devore told The Associated Press on Monday. "But what it really is, is an obsession about consuming the flesh of the other, and this can have a whole range of expressions. ... It is mostly played out in fantasy, mostly played out in role-playing."

There are well-known criminal extremes like Jeffrey Dahmer, who saved pieces of his victims' body parts and ate the flesh, Devore said, though "the instances of this kind of violence are extremely rare."

___

Associated Press writer Eileen AJ Connelly contributed to this report.

Source: http://news.yahoo.com/nyc-woman-husband-cop-wanted-kill-eat-222716178.html

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